• 1 in 3 Americans lose more than 20 hours of sleep each month due to pain, according to the American Alliance of Cancer Pain Initiatives (AACPI).

• According to the National Headache Foundation, headaches are the most common type of pain. It is estimated that industry loses $50 billion per year due to absenteeism and medical expenses caused by headaches.

• Pain is the second leading cause of medically related work absenteeism, resulting in more than 50 million lost workdays each year, according to the American Pain Society.

• There are more than 100 forms of arthritis. Currently more than 33 million Americans have arthritis. Nearly 90% of all persons over age 40 show beginning signs of arthritis or rheumatism (Lawrence, R.C., Hochberg, MC, Kelsy J.L., Journal of Rheumatology 16, 427-441)

• According to recent pain research by Hoffman and Tarzian ( "The Girl Who Cried Pain: A Bias Against Women In The Treatment of Pain" Law/ Med Ethics, 2001: 29:13-27), women are less likely to receive treatment for pain than men.

• Some 52 million informal and family caregivers provide care to people aged 20+ who are ill or disabled, according to the Department of Health and Human Services. Many caregivers consider pain to be an indication of the patient's status.

• Pain costs an estimated $100 billion each year. Every day, 60% of men and women experience some pain (AACPI).

• Of the community dwelling elderly, up to 50% can be expected to suffer from pain. Among institutionalized elderly 71% to 83% report at least one pain problem (L. Galieze, "Chronic Pain in Elderly People" Pain 1997 Mar., 70 (1): 3-14)

• Chronic pain not only causes physical discomfort, but also interferes with social relationships, family life and self-esteem. There is a high correlation between chronic pain and depression.